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Urocortin II
Urocortin 2 (Ucn2) is an endogenous peptide in the corticotrophin-releasing factor (CRF) family.〔Smani T, Calderon E, Rodriguea-Moyano M, Dominguez-Rodriguez A, Diaz I, Ordonez A. 2011. Urocortin-2 induces vasorelaxation of coronary arteries isolated from patients with heart failure. Clinical and Experimental Pharmacology and Physiology 38: 71-76.
〕 Immunohistochemistry analysis of human myocytes has shown greater immunoreactivity of Ucn2 in myocytes of the failing heart compared to those of the healthy heart. Researchers suggest this is a result of an innate mechanism in which Ucn2 acts to improve function of the failing heart (). The pathophysiology of heart failure is often a consequence of improper calcium handling and relaxation resulting in a lower cardiac output, decreased blood flow and overall decreased heart function (). Infusion of Ucn2 in healthy humans has shown a dose dependent increase in cardiac output, heart rate and left ventricle ejection fraction and a decrease in systemic vascular resistance (). Ucn2 has been studied as potential treatment for individuals with heart failure.
==Research findings==
The cardiovascular function of Ucn2 was assessed by Meili-Butz and her team who used isolated hearts from a rat model for hypertension heart disease with severe left ventricle dysfunction and heart failure. Hearts were assessed for left ventricle function, MAPD and VFT before and after perfusion with Ucn2 and compared with a control group. Infusion of Ucn2 resulted in an immediate and significant improvement in left ventricle function, increased coronary flow, significantly altered intracellular calcium handling and increased SR calcium (). These relaxation effects can be explained by the increased calcium clearance into the SR would assist in relaxation of the cell. Increased calcium in the SR by Ucn2 was studied by Dr. Yand LZ et al. and shown to be a result of Ucn2 mediated production of cAMP and phosphokinase A (PKA) (). This is consistent Nishikimi T. et al. findings that Ucn2 to increases cAMP levels in myocytes and nonmyocytes (). The production of PKA results in the phosphorylation of phospholamban and inhibition of its block on the sarcoendoplasmic reticulum calcium ATPase (SERCA) (). Additional research Smani T et al. studied the production of PKA by Ucn2 on rat coronary vessels. It was determined PKA mediated inhibition of calcium-independent phospholipase A and calcium influx which resulted in relaxation of the vasculature (). This suggests Ucn2 may be beneficial in improving blood but these findings have less biological applicability to human medicine as they were completed on rats. In 2011 a similar relationship was found in human heart(). Ucn2 produced a dose dependent relaxation of coronary. It was confirmed that this correlation was a result of the cAMP/ PKA pathway and independent of endothelial function. The researches suggested Ucn2 may be a beneficial drug in damaged hearts where the endothelium is not intact.〔1. Smani T, Calderon E, Rodriguea-Moyano M, Dominguez-Rodriguez A, Diaz I, Ordonez A. 2011. Urocortin-2 induces vasorelaxation of coronary arteries isolated from patients with heart failure. Clinical and Experimental Pharmacology and Physiology 38: 71-76.
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